Transcriptional profiling at the DLK1/MEG3 domain explains clinical overlap between imprinting disorders

Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders.

AIMS To examine the genetic overlap between borderline personality features (BPF) and substance use disorders (SUDs) and the extent to which variation in personality traits contributes to this covariance. DESIGN Genetic structural equation modelling was used to partition the variance in and covariance between personality traits, BPF and SUDs into additive genetic, shared and individual-specif...

Transcriptional control: Imprinting insulation

Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF.

The Clinical Implications of Overlap Between Constipation and Common Functional Gastrointestinal Disorders

Overlap Between Autism Spectrum Disorders and Attention Deficit Hyperactivity Disorder: Searching for Distinctive/Common Clinical Features

Recent studies support several overlapping traits between autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD), assuming the existence of a combined phenotype. The aim of our study was to evaluate the common or distinctive clinical features between ASD and ADHD in order to identify possible different phenotypes that could have a clinical value. We enrolled 181 sub...

Transcriptional profiling in cancer: the path to clinical pharmacogenomics.

Cancer is a major source of morbidity and mortality, second only to heart disease as the leading cause of death in most developed countries. Our ability to treat the disease depends heavily on our understanding its aetiology. Different types of cancer often respond best to different courses of treatment, yet our understanding of cancer classification remains imperfect. Novel expression-monitori...